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Bills vs. Texans prediction: Week 12 ‘Thursday Night Football’ picks, odds

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The Bills head to Houston to take on the Texans in a key Thursday night AFC matchup. 

While Buffalo improved to 7-3 with a win over the Buccaneers last Sunday, their biggest weakness showed its face once again. 

Tampa Bay ran wild against the Bills, rushing for a season-high 202 yards. 

Third-string running back Sean Tucker had a career day, going for 106 yards on the ground with three total touchdowns. 

Tucker had six rushes of 10-plus yards, including a 43-yard score in the second quarter. 

It was a continuation of the Bills’ entire season, and this week their run defense will face one of the most explosive young running backs in the NFL right as he’s hitting his stride. 

Heading into Week 12, the Bills have allowed the 2nd-most rushing yards per attempt (5.4) and 2nd-most rushing yards per game (153) this season. 


Houston Texans running back Woody Marks runs with the ball during the first half of an NFL football game against the San Francisco 49ers Sunday, Oct. 26, 2025, in Houston. AP

That’s good news for Woody Marks. 

The USC product has taken over the Texans’ backfield from veteran Nick Chubb, getting double-digit rushing attempts in each of his last five games, including a season-high 18 last week. 

Over the past four weeks, in a stretch that included some tough run defense like the Broncos, Jaguars, and 49ers, Marks has gone over 60 yards on the ground in two games. 


Betting on the NFL?


After weeks of sharing the backfield, Marks has essentially been a true RB1 for Houston over the last two weeks, playing in 80 percent of their snaps and 66 percent last week, which were his two highest totals this season. 

Look for Marks to have himself another solid showing on Thursday night. 

The play: Woody Marks Over 57.5 rushing yards (-120, bet365 Sportsbook)


Why Trust New York Post Betting

Dylan Svoboda is a versatile writer and analyst across many sports. He’s particularly knowledgeable about the big three — MLB, the NFL and the NBA.

[Notigroup Newsroom in collaboration with other media outlets, with information from the following sources]

Tags: bettingbuffalo billshouston texansnflnfl bettingSportssports bettingSports Picks
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