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Bills vs. Jaguars, Eagles vs. 49ers predictions: NFL Wild Card weekend picks, odds

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Gambling content 21+. The New York Post may receive an affiliate commission if you sign up through our links. Read our editorial standards for more information.

Sports betting writer Dylan Svoboda joins The Post’s Bettor’s Guide for his second season.

Buffalo Bills (+0.5) over JACKSONVILLE JAGUARS

With Josh Allen and Co. heading on the road to face the red-hot Jags, this is our tightest spread of the weekend.

I’m leaning on experience here.

While the Jaguars are everyone’s sleeper pick in the AFC, I’m not ready to trust Trevor Lawrence, who still has just one career playoff win, and first-year head coach Liam Coen. 

The Bills didn’t have the most convincing regular season, but they finished the year with impressive road wins in Pittsburgh, New England, and always-tough Cleveland. 

Allen, who has been visibly banged up for weeks, got some much-needed rest last week, playing just one snap in Week 18 against the Jets. 

Look for their superstar quarterback to play Superman with some fresh legs.


Philadelphia Eagles quarterback Jalen Hurts (1) hands off the ball to Philadelphia Eagles running back Saquon Barkley, left, during the first half of an NFL football game against the Las Vegas Raiders on Sunday, Dec. 14, 2025, in Philadelphia. AP

PHILADELPHIA EAGLES (-4) over San Francisco 49ers

A week ago, the 49ers had a shot at a first-round bye with the potential to never leave the Bay Area through the Super Bowl.  

It’s all gone wrong for them since then. They lost to the Seahawks, missed the NFC’s No. 1 seed, and suffered even more injuries to their already depleted roster.

Linebacker Tatum Bethune went down with a groin injury, and it appears dicey at best that the team will get star left tackle Trent Williams and wide receiver Ricky Pearsall, who both didn’t practice on Wednesday, back on Sunday. 


Betting on the NFL?


It’s amazing this team has even gotten this far.

Traveling across the country isn’t going to help, and it will be tough to turn this game into a shootout against the Eagles’ defense. 

San Francisco’s luck might run out on Sunday.

LAST WEEK: 1-1.

2025 SEASON: 15-21.


Why Trust New York Post Betting

Dylan Svoboda is a versatile writer and analyst across many sports. He’s particularly knowledgeable about the big three — MLB, the NFL and the NBA.

[Notigroup Newsroom in collaboration with other media outlets, with information from the following sources]

Tags: bettingbettor's guidebuffalo billsjacksonville jaguarsnflnfl bettingphiladelphia eaglessan francisco 49ersSportssports bettingSports Picks
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