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Bills vs. Browns, Saints vs. Jets predictions: NFL Week 16 picks, odds

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New York Jets head coach Aaron Glenn speaks in a press conference after an NFL football game against the Jacksonville Jaguars, Sunday, Dec. 14, 2025, in Jacksonville, Fla.
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Sports betting writer Dylan Svoboda joins noti.group’s Bettor’s Guide for his second season.

NEW ORLEANS SAINTS (-4) over New York Jets

The Saints have something in Tyler Shough. 

New Orleans has won two straight, spoiling the divisional hopes of the Buccaneers and Panthers, and three of six games with the Louisville product as their QB1. 

They’ll get to face a Jets defense that’s crumbling right before our eyes. 

Last week, the Jets allowed 438 total yards and 48 points to Trevor Lawrence and Co.

It wasn’t much better a week earlier when they let the now-benched Tua Tagovailoa and the Dolphins’ strong running attack go nuts, beating the Jets 34-10. 

Given their draft position and quarterback situation — Brady Cook will once again be behind center on Sunday — the Jets may prefer to lose out.

It doesn’t appear that the same can be said about Shough and the Saints. 


New York Jets head coach Aaron Glenn speaks in a press conference after an NFL football game against the Jacksonville Jaguars, Sunday, Dec. 14, 2025, in Jacksonville, Fla. AP

Buffalo Bills (-10) over CLEVELAND BROWNS

The Shedeur Sanders experience has taken a turn. 

After showing flashes during his first three starts, Sanders showed last week why he dropped all the way to the fifth round. 

In a blowout loss to the Bears, Sanders threw three picks while being sacked five times. 

Cleveland’s run game had zero chance at getting going, gaining just 50 yards on the ground.


Betting on the NFL?


The Bills’ defense isn’t a world beater, but this quarterback matchup is about as much of a mismatch as it can get. 

With the AFC’s No. 1 seed still a possibility, look for Buffalo to come out to play. 

LAST WEEK: 0-2.

2025 SEASON: 13-17.


Why Trust New York Post Betting

Dylan Svoboda is a versatile writer and analyst across many sports. He’s particularly knowledgeable about the big three — MLB, the NFL and the NBA.

[Notigroup Newsroom in collaboration with other media outlets, with information from the following sources]

Tags: bettingbettor's guidebuffalo billscleveland brownsnew orleans saintsnew york jetsnflnfl bettingSportssports bettingSports Picks
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