--- title: "Researchers Identify Effective Anti-Aging Treatments" url: https://noti.group/researchers-identify-effective-anti-aging-treatments/ language: en publisher: "Noti Group" section: "Health" published: 2026-11-14T04:26:12.000Z updated: 2026-11-14T08:26:42.395Z id: 65f3abf7-1084-4064-8519-0b5918825c9f source: "ScienceDaily Health https://www.sciencedaily.com/releases/2026/11/261112230452.htm" attribution: "Link to https://noti.group/researchers-identify-effective-anti-aging-treatments/ and name Noti Group when you quote or summarize this story." --- # Researchers Identify Effective Anti-Aging Treatments Scientists at Yale University have made significant progress in identifying which treatments can slow down biological aging by analyzing various existing approaches to slowing aging. Scientists at Yale University have made significant progress in identifying which treatments can slow down biological aging and which ones have little impact. Their research shows that certain prescription medications and lifestyle changes can actually reduce biological age as measured by DNA-based blood tests. These findings could revolutionize the way scientists evaluate anti-aging treatments, allowing them to focus on effective interventions rather than ineffective ones. The study's lead researcher, Raghav Sehgal, had initially planned to investigate cancer using advanced computer science techniques. However, his research direction changed after a conversation with his Ph.D. adviser at the Yale School of Medicine. Sehgal's adviser suggested that he explore the aging process itself, rather than focusing on individual diseases such as cancer or cardiovascular disease. "That put me on a different path," Sehgal explained, noting that researchers still have much to learn about the aging process and whether current treatments actually work. Sehgal's current research focuses on understanding the biological mechanisms that underlie human aging. He is particularly interested in determining how scientists can accurately measure these changes and why they increase the risk of age-related conditions such as cancer, diabetes, and dementia. The study explores whether certain interventions could potentially reverse some aspects of biological aging, even if completely eliminating aging remains an unattainable goal. To answer this question, Sehgal's team has been conducting a comprehensive analysis of various existing approaches to slowing aging. Their research found that some medications and lifestyle changes have measurable effects on the body. In contrast, over-the-counter supplements generally failed to produce significant reductions in biological age. The study involved a collaborative effort from the entire Higgins-Chen laboratory, with contributions from several team members including Daniel Borrus, Jenel F. Armstrong, John Gonzalez, Jessica Kasamoto, and Yaroslav Markov. For the first time, Sehgal's team has demonstrated that certain therapies have measurable impacts on aging. This breakthrough is significant because it allows researchers to say which biomarkers are consistently responsive to specific interventions for the first time. The researchers analyzed chemical patterns attached to DNA, specifically methyl groups that act as tags, which change as people grow older according to previous research. The team compiled findings from 51 clinical studies on various anti-aging strategies, including dietary supplements and medications, lifestyle changes, and medical procedures, to identify effective interventions. By examining over 110 DNA methylation biomarkers across these studies, the researchers compared measurements taken before and after interventions to evaluate which approaches were associated with reductions in biological age. The study's novelty lies in combining existing knowledge from animal models and retrospective analysis with real-world clinical data to pinpoint effective human interventions. Interventions were categorized into four main groups: prescription drugs, lifestyle modifications, over-the-counter supplements, and medical procedures, to identify the most promising approaches. Certain pharmaceutical treatments have shown significant promise in reducing biological age markers. These medications include metformin and semaglutide, used to manage metabolic conditions and body weight, as well as anti-TNF therapies that target inflammatory responses. The studies examined revealed that these treatments can lead to substantial decreases in epigenetic age markers. This is particularly noteworthy given the critical role of these biomarkers in assessing an individual's aging process. A different story emerges when considering over-the-counter supplements and certain medical procedures. In contrast to pharmaceutical treatments, these approaches failed to yield measurable reductions in biological age markers. The findings also highlight the importance of utilizing newer biological age clocks, which have proven more accurate than their older counterparts. Furthermore, individuals living with diseases tend to exhibit larger changes in aging biomarkers compared to healthy participants. To advance aging research, scientists may soon use validated biological age measurements to identify promising treatments much earlier than relying solely on clinical studies that span decades. However, interpreting changes in aging biomarkers requires caution, and senior author Higgins-Chen emphasizes the importance of fully understanding their meaning. The results are encouraging, but several critical questions remain unanswered. For instance, researchers need to determine whether changes in biological age are directly caused by a treatment or influenced by other factors that were overlooked during the study. To clarify these uncertainties, further investigations are underway, with studies led by Borrus, Armstrong, and Grace Zou aimed at establishing key details about the relationship between aging biomarkers and interventions. The analysis of improved DNA-based blood tests by Yale researchers has shed light on several interventions that may influence biological aging. Two promising approaches have emerged from this research: certain anti-TNF medications have shown benefits in reducing biological age markers, while other treatments and supplements have yielded little measurable effect. Some medical procedures have also been found to have a negligible impact on lowering biological age, leaving researchers with more questions than answers about the effectiveness of these interventions. The findings suggest that further research is necessary to confirm the results and determine whether reductions in biological age markers can lead to better health outcomes and increased longevity. --- Source: [ScienceDaily Health](https://www.sciencedaily.com/releases/2026/11/261112230452.htm) Published by Noti Group: https://noti.group/researchers-identify-effective-anti-aging-treatments/